Friday, July 15th. Neural mechanisms underlying human cognitive control and working memory
Memory, Cognition and In Between
In memoriam: Fani Adelmann
Tel Aviv, March 24, 2022
Zheng J, Schjetnan AGP, Yebra M, Mosher C, Kalia S, Valiante TA, Mamelak A, Kreiman G, Rutishauser U (2021). Cognitive boundary signals in the human medial temporal lobe shape episodic memory representation. Nature Neuroscience 25:358-368 PDF
Misra P, Marconi A, Petterson M, Kreiman G. (2018) Minimal memory for details in real-life events. Scientific Reports, 8, 16701. PDF
Tang H, Singer J, Ison M, Pivazyan G, Romaine M, Frias R, Meller E, Boulin A, Carroll JD, Perron V, Dowcett S, Arlellano M, Kreiman G. (2016). Predicting episodic memory formation for movie events. Scientific Reports, 6:30175. PDF
We hope that you will be able to join next week’s research meeting with presentations by Mengmi Zhang and Jie Zheng, Kreiman Lab.
CBMM Research Meeting
Title: Module 2 Research presentation
Date/Time: October 26, 2021, 4:00 pm to 5:30 pm ET
Jie Zheng‘s presentation (in person):
Title: Neurons that structure memories of ordered experience in human
Abstract: The process of constructing temporal associations among related events is essential to episodic memory. However, what neural mechanism helps accomplish this function remains unclear. To address this question, we recorded single unit activity in humans while subjects performed a temporal order memory task. During encoding, subjects watched a series of clips (i.e., each clip consisted of 4 events) and were later instructed to retrieve the ordinal information of event sequences. We found that hippocampal neurons in humans could index specific orders of events with increased neuronal firings (i.e., rate order cells) or clustered spike timing relative to theta phases (i.e., phase order cells), which are transferrable across different encoding experiences (e.g., different clips). Rate order cells also increased their firing rates when subjects correctly retrieved the temporal information of their preferred ordered events. Phase order cells demonstrated stronger phase precessions at event transitions during encoding for clips whose ordinal information was subsequently correct retrieved. These results not only highlight the critical role of the hippocampus in structuring memories of continuous event sequences but also suggest a potential neural code representing temporal associations among events.
Mengmi Zhang‘s [virtual] presentation:
Title: Visual Search Asymmetry: Deep Nets and Humans Share Similar Inherent Biases
Abstract: Visual search is a ubiquitous and often challenging daily task, exemplified by looking for the car keys at home or a friend in a crowd. An intriguing property of some classical search tasks is an asymmetry such that finding a target A among distractors B can be easier than finding B among A. To elucidate the mechanisms responsible for asymmetry in visual search, we propose a computational model that takes a target and a search image as inputs and produces a sequence of eye movements until the target is found. The model integrates eccentricity-dependent visual recognition with target-dependent top-down cues. We compared the model against human behavior in six paradigmatic search tasks that show asymmetry in humans. Without prior exposure to the stimuli or task-specific training, the model provides a plausible mechanism for search asymmetry. We hypothesized that the polarity of search asymmetry arises from experience with the natural environment. We tested this hypothesis by training the model on an augmented version of ImageNet where the biases of natural images were either removed or reversed. The polarity of search asymmetry disappeared or was altered depending on the training protocol. This study highlights how classical perceptual properties can emerge in neural network models, without the need for task-specific training, but rather as a consequence of the statistical properties of the developmental diet fed to the model. Our work will be presented in the upcoming Neurips conference, 2021.
See also: Gupta SK, Zhang M, Wu CC, Wolfe JM, Kreiman G (2021). Visual search asymmetry: deep nets and humans share similar inherent biases. NeurIPS PDF
Jie Zheng. February 03, 2021
While experience is continuous, memories are organized as discrete events. Cognitive boundaries are thought to segment experience and structure memory, but how this process is implemented remains unclear. We recorded the activity of single neurons in the human medial temporal lobe during the formation and retrieval of memories with complex narratives. Neurons responded to abstract cognitive boundaries between different episodes. Boundary-induced neural state changes during encoding predicted subsequent recognition accuracy but impaired event order memory, mirroring a fundamental behavioral tradeoff between content and time memory. Furthermore, the neural state following boundaries was reinstated during both successful retrieval and false memories. These findings reveal a neuronal substrate for detecting cognitive boundaries that transform experience into mnemonic episodes and structure mental time travel during retrieval.
Congratulations to Cognitive Neuroscience Society Postdoctoral Fellow Awardee Jie Zheng!
See also recent publication from Jie Zheng:
Zheng J, Schjetnan AGP, Yebra M, Mosher C, Kalia S, Valiante TA, Mamelak A, Kreiman G, Rutishauser U (2021). Cognitive boundary signals in the human medial temporal lobe shape episodic memory representation. bioRxiv. 01.16.426538 PDF