Tag: sleep

Building a Map of the Human Brain Functional Connections at the Mesoscale

Post author By klab coordinator
Post date December 7, 2021

https://brain.harvard.edu/hbi_news/building-a-map-of-the-human-brain-functional-connections-at-the-mesoscale/

PDF Wang J, Tao A, Anderson WS, Madsen JR, Kreiman G (2021). Mesoscopic physiological interactions in the human brain reveal small world properties. Cell Reports, 36 (8) 109585. Supplementary Material | Resources

Cognition relies on rapid and robust communication between brain areas. Wang et al. leverage multi-day intracranial field potential recordings to characterize the human mesoscopic functional interactome. They validated the methods using monkey anatomical and physiological data. The human interactome reveals small-world properties and is modulated by sleep versus awake state.

Tags human brain interactome, human neurophysiology, interactions between brain areas, intracranial field potentials, mesoscopic connectivity, sleep, small-world properties

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10	11 Katarina, Gabriel \| … Katarina, Gabriel \| Meeting with Prof. Kreiman January 11, 2022 5:00 pm - 6:00 pm https://bit.ly/3w6NB1p Zoom link: https://bit.ly/3w6NB1p See more details •	12 Kreiman Lab Meeting Kreiman Lab Meeting January 12, 2022 5:00 pm - 7:00 pm Dr Gabriel Kreiman is inviting you to a scheduled Zoom meeting. Topic: KLAB lab meeting Time: Oct 14, 2020 12:00 PM Eastern Time (US and Canada) Every week on Wed, until Nov 4, 2020, 4 occurrence(s) Oct 14, 2020 12:00 PM Oct 21, 2020 12:00 PM Oct 28, 2020 12:00 PM Nov 4, 2020 12:00 PM See more details •	13 Systems Club. He Tia… Systems Club. He Tian: All-optical electrophysiology reveals interneuron network dynamics in vivo January 13, 2022 5:15 pm - 6:15 pm SysClub is back this Thursday - 1/13/21. He Tian from the Cohen lab will be presenting her talk: “All-optical electrophysiology reveals interneuron network dynamics in vivo.” Here is a description to the talk and link to a pre-print of some of the work: “All-optical electrophysiology can be a powerful tool for studying neural dynamics in vivo, as it offers the ability to image and perturb membrane voltage in multiple cells simultaneously. The “Optopatch” constructs combine a red-shifted archaerhodopsin (Arch)-derived genetically encoded voltage indicator (GEVI) with a blue-shifted channelrhodopsin actuator (ChR). We used a video-based pooled screen to evolve Arch-derived GEVIs with improved signal-to-noise ratio (QuasAr6a) and kinetics (QuasAr6b). By combining optogenetic stimulation of individual cells with high-precision voltage imaging in neighboring cells, we mapped inhibitory and gap junction-mediated connections, in vivo. Optogenetic activation of a single NDNF-expressing neuron in visual cortex Layer 1 significantly suppressed the spike rate in some neighboring NDNF interneurons. Hippocampal PV cells showed near-synchronous spikes across multiple cells at a frequency significantly above what one would expect from independent spiking, suggesting that collective inhibitory spikes may play an important signaling role in vivo. By stimulating individual cells and recording from neighbors, we quantified gap junction coupling strengths. Together, these results demonstrate powerful new tools for all-optical microcircuit dissection in live mice.” Due to current Harvard event restrictions, we will only be holding this talk over Zoom. Please join us at 12:15pm in this meeting room. See more details •	14	15	16
17	18 Katarina, Gabriel \| … Katarina, Gabriel \| Meeting with Prof. Kreiman January 18, 2022 5:00 pm - 6:00 pm https://bit.ly/3w6NB1p Zoom link: https://bit.ly/3w6NB1p See more details •	19 Kreiman lab presenta… Kreiman lab presentation at Lab Results January 19, 2022 2:30 pm - 3:30 pm Yuchen Xiao will be giving a talk. Title = "Task-specific neural processes underlying conflict resolution during cognitive control" (unless Yuchen says otherwise). See more details Kreiman lab presenta… Kreiman lab presentation at Kirby Lab Results January 19, 2022 2:30 pm - 3:30 pm See more details Kreiman Lab Meeting Kreiman Lab Meeting January 19, 2022 5:00 pm - 7:00 pm Dr Gabriel Kreiman is inviting you to a scheduled Zoom meeting. Topic: KLAB lab meeting Time: Oct 14, 2020 12:00 PM Eastern Time (US and Canada) Every week on Wed, until Nov 4, 2020, 4 occurrence(s) Oct 14, 2020 12:00 PM Oct 21, 2020 12:00 PM Oct 28, 2020 12:00 PM Nov 4, 2020 12:00 PM See more details • • •	20	21	22	23
24	25 Katarina, Gabriel \| … Katarina, Gabriel \| Meeting with Prof. Kreiman January 25, 2022 5:00 pm - 6:00 pm https://bit.ly/3w6NB1p Zoom link: https://bit.ly/3w6NB1p See more details •	26 Kreiman Lab Meeting Kreiman Lab Meeting January 26, 2022 5:00 pm - 7:00 pm Dr Gabriel Kreiman is inviting you to a scheduled Zoom meeting. Topic: KLAB lab meeting Time: Oct 14, 2020 12:00 PM Eastern Time (US and Canada) Every week on Wed, until Nov 4, 2020, 4 occurrence(s) Oct 14, 2020 12:00 PM Oct 21, 2020 12:00 PM Oct 28, 2020 12:00 PM Nov 4, 2020 12:00 PM See more details •	27	28	29	30
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January 2022