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Kreiman Lab News

Jerry Wang publishes landmark study on human brain interactome

Wang et al 2021 Human Brain Interactome
Wang et al Cell Reports 2021. Human brain interactome

Cognition relies on rapid and robust communication between brain areas. Wang et al. leverage multi-day intracranial field potential recordings to characterize the human mesoscopic functional interactome. The methods are validated using monkey anatomical and physiological data. The human interactome reveals small-world properties and is modulated by sleep versus awake state.

  • Recorded continuous intracranial field potentials for 5 days in 48 human subjects
  • Characterized functional mesoscopic interactome assessed by pairwise coherence
  • Validated methods using anatomical and physiological interactions in monkeys
  • Human functional interactome shows small-world graph and changes with brain state

Mesoscopic functional interactions in the human brain reveal small-world properties

Wang J, Anderson WS, Masen JR, Kreiman G

Cell Reports 8 (6), 2021

Resources

PDF

Supplementary Material

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Kreiman Lab News

Congratulations to Leonardo Pollina!

Leonardo Pollina
Leonardo Pollina, M. Sc.

Leonardo Pollina successfully defended his Master’s Thesis

His thesis is entitled: “Combining neurophysiology and computational modeling through VGG19”

Leonardo’s work was supported by the Bertarelli Foundation

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Kreiman Lab News

Congratulations Dr. Jerry Wang!

Jerry Wang Acadia
Jerry Wang climbing Bee Hive Trail in Acadia, circa 2017

February 16, 2021. Dr. Jerry Wang has successfully defended his Ph.D. thesis. In the words of the thesis examiners, “Herculean computational work”, “A landmark study”. Congratulations Dr. Wang!

See also Jerry Wang’s recent publication: Wang J, Tao A, Anderson WS, Madsen JR, Kreiman G (2021). Mesoscopic physiological interactions in the human brain reveal small world properties. Cell Reports 36 (8) 109585

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Kreiman Lab News

Neurons detect cognitive boundaries to structure episodic memories in humans

Jie Zheng. February 03, 2021

While experience is continuous, memories are organized as discrete events. Cognitive boundaries are thought to segment experience and structure memory, but how this process is implemented remains unclear. We recorded the activity of single neurons in the human medial temporal lobe during the formation and retrieval of memories with complex narratives. Neurons responded to abstract cognitive boundaries between different episodes. Boundary-induced neural state changes during encoding predicted subsequent recognition accuracy but impaired event order memory, mirroring a fundamental behavioral tradeoff between content and time memory. Furthermore, the neural state following boundaries was reinstated during both successful retrieval and false memories. These findings reveal a neuronal substrate for detecting cognitive boundaries that transform experience into mnemonic episodes and structure mental time travel during retrieval.

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Kreiman Lab News

Human Single Neuron Meeting Virtual Edition

Human Single Neuron Meeting 2020
Human Single Neuron Meeting 2020

We are proud to welcome you to the 5th International Meeting on Human single-neuron recordings, which will take place virtually on Friday November 13, 2020. This meeting will be an all-live event lasting approximately 4h, hosted on zoom, starting at 8am PST till noon PST (11am EST, 4pm European Central time).
 
This meeting is the successor to the previous four highly successful meetings (2011 at NYU, 2014 at Johns Hopkins, 2016 at Caltech, 2018 at Caltech). 

As a result of the previous meetings, we published the edited book “Single Neuron Studies of the Human Brain – Probing Cognition” by MIT Press in 2014.