Cognition relies on rapid and robust communication between brain areas. Wang et al. leverage multi-day intracranial field potential recordings to characterize the human mesoscopic functional interactome. The methods are validated using monkey anatomical and physiological data. The human interactome reveals small-world properties and is modulated by sleep versus awake state.
- Recorded continuous intracranial field potentials for 5 days in 48 human subjects
- Characterized functional mesoscopic interactome assessed by pairwise coherence
- Validated methods using anatomical and physiological interactions in monkeys
- Human functional interactome shows small-world graph and changes with brain state
Mesoscopic functional interactions in the human brain reveal small-world properties
Wang J, Anderson WS, Masen JR, Kreiman G
Cell Reports 8 (6), 2021