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Neurons detect cognitive boundaries to structure episodic memories in humans

Jie Zheng. February 03, 2021

While experience is continuous, memories are organized as discrete events. Cognitive boundaries are thought to segment experience and structure memory, but how this process is implemented remains unclear. We recorded the activity of single neurons in the human medial temporal lobe during the formation and retrieval of memories with complex narratives. Neurons responded to abstract cognitive boundaries between different episodes. Boundary-induced neural state changes during encoding predicted subsequent recognition accuracy but impaired event order memory, mirroring a fundamental behavioral tradeoff between content and time memory. Furthermore, the neural state following boundaries was reinstated during both successful retrieval and false memories. These findings reveal a neuronal substrate for detecting cognitive boundaries that transform experience into mnemonic episodes and structure mental time travel during retrieval.

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Kreiman Lab News

Congratulations Jie Zheng!

Congratulations to Cognitive Neuroscience Society Postdoctoral Fellow Awardee Jie Zheng!

Jie Zheng
Jie Zheng

See also recent publication from Jie Zheng:

Zheng J, Schjetnan AGP, Yebra M, Mosher C, Kalia S, Valiante TA, Mamelak A, Kreiman G, Rutishauser U (2021). Cognitive boundary signals in the human medial temporal lobe shape episodic memory representation. bioRxiv. 01.16.426538 PDF

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Kreiman Lab News

The formation of episodic memories in the human brain

The formation of episodic memories in the human brain. Gabriel Kreiman.

Klingenstein-Simons Meeting. New York.

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Kreiman Lab News

Brain prosthesis devices to improve memory

Article 1: Researchers to develop ‘brain prosthesis’ to help brain-injured patients recover memory.

Article 2: DARPA awards UCLA $15 million to restore lost memory.

Article 3: UCLA Campus Report: A Brain Prosthesis That Helps Recover Memory, More.